Table 1. Pancreatic histological sections from mice of the indicated age stained with anti-insulin antibodies and with Hoechst 33342 were used to determine the indicated parameters (see material and methods).

Week 5	Parameter	NOD	NOD-RIPN
	Area of insulin positive cells (% of pancreas section)	0.61±0.26	0.89±0.12
	Single islet surface (µm2)	3868±1804	4471±996
	Number of insulin positive cells per islet	19±8	21±4
	Number of islets per section	29±7	37±12
	Area of a single insulin positive cell (µm2)	202±41	211±34

Six female mice per genotype and per age were used (one section per animal). The results are represented as mean±95% CI. There was no statistical significant difference between NOD and NOD-RIPN mice as assessed by Student t test for any of the tested parameter.