Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Jul 25;6(7):e22713. doi: 10.1371/journal.pone.0022713

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Aletrari et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

A. Typical single cytotoxicity profiles of DMSO, ES_I and ES_R35 treated HeLa cells subsequently challenged with graded doses of DTx for 2 (upper) or 4 h (lower). B. Protective effect of the drugs, determined from assays in A. n = 3, +/− 1.S.D. Protective effects from ES_I and ES_R35 treated cells were compared using an unpaired t-test (2 h, p = 0.0104, t = 4.555; 4 h, p = .00024, t = 6.858; *, significant: **, very significant). C. Typical single assays showing the temporal profile of DTx cytotoxicity to cells treated with DMSO, ES_I or ES_R35, and determination of the lag phase (dotted lines and arrowheads, coded as in Figure 3C). D. Lag phases and half-lives of protein synthesis (T_1/2) were determined. DMSO, n = 6, +/− 1.S.D., ES_I and ES_R35, n = 3, +/− 1 S.D. Values were compared using unpaired t-tests. Lags: DMSO versus ES_R35, no significant difference; DMSO versus ES_I, p<0.0001, t = 8.810; ES_I versus ES_R35 p = 0.0028, t = 6.573; **, very significant: ***, extremely significant. T_1/2 values: no significant differences.