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. Author manuscript; available in PMC: 2012 Sep 1.

Published in final edited form as: Biochim Biophys Acta. 2011 May 30;1812(9):1130–1137. doi: 10.1016/j.bbadis.2011.05.007

Cell growth and morphologic changes of HUVEC treated with high glucose and AGE. HUVE cells were treated for 24h with A: PBS control; B: high mannitol control (30 mmol/L); C: high glucose (30 mmol/L); D: high glucose + atorvastatin (12 mg/L); E: high AGE (400 μg/ml); F: high AGE with atorvastatin (12 mg/L); G: Cell death in each treatment group (quantitated as dead cells/microscopic field). Data are expressed as mean ± SD in each group. * compared with the control group, P<0.05; ** compared with the high glucose group, P<0.05; *** compared with the AGE group, P=0.5. Photos were taken 24 hours after treatment. (Dead cells are shown in yellow).

Cell growth and morphologic changes of HUVEC treated with high glucose and AGE. HUVE cells were treated for 24h with A: PBS control; B: high mannitol control (30 mmol/L); C: high glucose (30 mmol/L); D: high glucose + atorvastatin (12 mg/L); E: high AGE (400 μg/ml); F: high AGE with atorvastatin (12 mg/L); G: Cell death in each treatment group (quantitated as dead cells/microscopic field). Data are expressed as mean ± SD in each group. * compared with the control group, P<0.05; ** compared with the high glucose group, P<0.05; *** compared with the AGE group, P=0.5. Photos were taken 24 hours after treatment. (Dead cells are shown in yellow).