Skip to main content
. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Bone. 2011 May 15;49(3):356–367. doi: 10.1016/j.bone.2011.05.008

Figure 1. Unsupervised hierarchical clustering defines two osteosarcoma subtypes characterized by two reciprocal gene clusters.

Figure 1

(A) Unsupervised Clustering using expression data corresponding to 17,482 Entrez Gene IDs reveals two major branches in 26 dogs with osteosarcoma and one dogs with non-malignant osteomyelitis (OSCA 41), identified respectively as Branch A and Branch B in the toe bar. (B) Heat map showing 282 differentially expressed transcripts (p ≤0.0068, mean average fold-change >3) divided into two reciprocally expressed gene clusters (Gene Cluster 1 and Gene Cluster 2) between dogs in Branch A and Branch B. Heat map colors represent median-centered fold change expression following log2 transformation (a quantitative representation of the colors is provided in the scale at the bottom). Up-regulated genes are shown in red and down-regulated genes are shown in green.