Skip to main content
. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Glia. 2011 May 19;59(10):1402–1413. doi: 10.1002/glia.21178

Figure 6.

Figure 6

Alternative activation of microglia in vivo is influenced by p53. A) Tissue sections from the ischemic penumbra region of p53+/+ and p53−/− mice labeled for CD206 reveal an increased number of ramified parenchymal microglia in p53 deficient mice compared with p53+/+ control, but no change in the number of CD206 positive perivascular macrophages (Grey arrows=microglia, black arrows=perivascular macrophages). B) The percent increase in CD206 labeled microglia ipsilateral to the MCAO is significantly increased (*p<0.05 by t-test, n=4) in p53 deficient mice compared with the increase observed in p53 expressing mice.