Table 5.

Multivariate Predictors of Response and Toxicity: First Time Treatments

	Response (CR+PR)			Toxicity (CTCAE ≥ 3)
	Predictor	OR (95% CI)	p Value	Predictor	OR (95% CI)	p Value
HILP	Age (≥ 60 y)	0.33 (0.07-1.53)	0.155	Age (≥ 60 y)	4.61 (0.66-32.18)	0.123
	Female sex	2.60 (0.60-11.33)	0.203	Female sex	0.12 (0.01-1.39)	0.090
	Lower limb*			Lower limb*
	Corrected IBW*			Corrected IBW*
	Disease stage*			Disease stage*
	High disease burden*			High disease burden	0.46 (0.07-2.92)	0.408
ILI	Age (≥ 60 y)	2.61 (0.96-7.01)	0.060	Age (≥ 60 y)*
	Female sex*			Female sex*
	Lower limb	19.32 (2.61-142.50)	0.004	Lower limb*
	Melphalan dose	0.94 (0.90-0.99)	0.009	Melphalan dose	0.95 (0.92-0.99)	0.010
	Papavarine use*			Papavarine use*
	Corrected IBW*			Corrected IBW	13.09 (2.94-58.35)	0.001
	Base excess	0.90 (0.76-1.06)	0.190	Base excess*
	PaO2	0.88 (0.77-1.00)	0.044	PaO2*
	pH*			pH *
	Ischemia	1.02 (0.99-1.06)	0.230	Ischemia	1.05 (1.00-1.10)	0.032
	Limb volume*			Limb volume*
	Weight*			Weight*
	Height*			Height	0.97 (0.91-1.03)	0.294
	Peak temperature	1.53 (0.77-3.03)	0.220	Peak temperature*
	Disease stage	1.51 (0.65-3.50)	0.330	Disease stage	3.68 (1.25-10.84)	0.018
	High disease burden	0.51 (0.19-1.39)	0.190	High disease burden*

^*Predictor did not meet inclusion criteria for model.

CR+PR, complete response + partial response; CTCAE, Common Terminology Criteria for Adverse Events; HILP, hyperthermic isolated limb perfusion; IBW, ideal body weight; ILI, isolated limb infusion.