Figure 3.

Murine nasal transepithelial chloride transport is partially IRF-1 dependent. Changes in TEPD in response to perfusion with chloride-free Ringer’s solution were measured in wild-type C57BL/6J mice (filled squares; n = 6), IRF-1^–/– mice (open circles; n = 8), and IRF-1^–/– mice with SNP (100 μM) added to the perfusion solution (filled triangles; n = 5). Error bars represent SEM. Time zero refers to the point at which the perfusion solution was changed to chloride-free Ringer’s (this was done when a plateau value was reached in chloride-replete Ringer’s containing amiloride). Amiloride (100 μM) was present in all perfusion solutions.