Table 5.

Association between orthostatic hypotension, quartiles of systolic blood pressure response (ΔSBP) and cause-specific mortality among 5,805 participants of the rescreening program within Malmö Preventive Project

Causes of death Hazard ratio [95% CI]	OH status		Quartiles of ΔSBP (mmHg)*
	Negative (reference) n = 5,235 (P value)	Positive n = 570	Q1†SBP +8.7 ± 4.6 n = 1,300 (P linear trend)	Q2SBP 0.0 ± 0.0 n = 1,713	Q3SBP −5.0 ± 0.1 n = 1,024	Q4SBP −14.2 ± 6.0 n = 1,768
All causes	n = 1,537	n = 232	n = 338	n = 496	n = 295	n = 640
Model 1	1.00 <0.001	1.47 [1.28–1.68]	1.00 <0.001	1.12 [0.98–1.29]	1.11 [0.95–1.30]	1.40 [1.23–1.60]
Model 2	1.00 0.001	1.29 [1.12–1.48]	1.00 0.002	1.11 [0.97–1.28]	1.08 [0.92–1.26]	1.25 [1.09–1.43]
Cancer	n = 599	n = 66	n = 141	n = 190	n = 124	n = 210
Model 1	1.00 0.59	1.07 [0.83–1.38]	1.00 0.30	1.03 [0.83–1.28]	1.12 [0.88–1.43]	1.10 [0.89–1.37]
Model 2	1.00 0.82	1.03 [0.80–1.34]	1.00 0.41	1.05 [0.84–1.30]	1.12 [0.88–1.43]	1.09 [0.87–1.35]
Cardiovascular	n = 582	n = 113	n = 132	n = 184	n = 97	n = 282
Model 1	1.00 <0.001	1.88 [1.53–2.29]	1.00 <0.001	1.07 [0.85–1.33]	0.93 [0.72–1.21]	1.56 [1.27–1.92]
Model 2	1.00 <0.001	1.54 [1.24–1.89]	1.00 0.021	1.01 [0.81–1.26]	0.87 [0.67–1.14]	1.27 [1.02–1.57]
IHD	n = 387	n = 82	n = 80	n = 128	n = 64	n = 197
Model 1	1.00 <0.001	2.06 [1.62–2.61]	1.00 <0.001	1.23 [0.93–1.62]	1.02 [0.73–1.41]	1.80 [1.39–2.34]
Model 2	1.00 <0.001	1.65 [1.29–2.12]	1.00 0.011	1.15 [0.87–1.53]	0.97 [0.69–1.34]	1.43 [1.10–1.87]
Cerebrovascular	n = 94	n = 11	n = 26	n = 25	n = 17	n = 37
Model 1	1.00 0.72	1.12 [0.60–2.09]	1.00 0.67	0.74 [0.43–1.27]	0.83 [0.45–1.52]	1.03 [0.62–1.70]
Model 2	1.00 0.77	0.91 [0.48–1.73]	1.00 0.71	0.71 [0.41–1.23]	0.75 [0.40–1.39]	0.84 [0.50–1.42]
Injuries	n = 59	n = 12	n = 10	n = 16	n = 16	n = 29
Model 1	1.00 0.034	1.96 [1.05–3.65]	1.00 0.013	1.23 [0.56–2.71]	2.06 [0.93–4.53]	2.16 [1.05–4.44]
Model 2	1.00 0.066	1.82 [0.96–3.46]	1.00 0.03	1.20 [0.54–2.65]	1.94 [0.88–4.29]	1.98 [0.95–4.15]
Respiratory	n = 96	n = 23	n = 17	n = 25	n = 24	n = 53
Model 1	1.00 <0.001	2.30 [1.46–3.62]	1.00 <0.001	1.12 [0.60–2.07]	1.78 [0.95–3.31]	2.28 [1.32–3.94]
Model 2	1.00 0.024	1.73 [1.07–2.78]	1.00 0.005	1.22 [0.65–2.28]	1.80 [0.95–3.39]	2.03 [1.14–3.60]
Digestive	n = 42	n = 6	n = 10	n = 16	n = 8	n = 14
Model 1	1.00 0.41	1.44 [0.61–3.39]	1.00 0.95	1.23 [0.56–2.72]	1.04 [0.41–2.64]	1.10 [0.49–2.50]
Model 2	1.00 0.66	1.22 [0.50–2.97]	1.00 0.83	1.15 [0.51–2.56]	1.03 [0.41–2.63]	0.96 [0.42–2.23]
Neurological	n = 39	n = 4	n = 3	n = 14	n = 8	n = 18
Model 1	1.00 0.97	1.02 [0.37–2.86]	1.00 0.022	3.60 [1.03–12.52]	3.43 [0.91–12.94]	4.59 [1.35–15.62]
Model 2	1.00 0.85	1.11 [0.39–3.16]	1.00 0.008	3.68 [1.06–12.85]	3.69 [0.98–13.97]	5.46 [1.57–18.92]
Other causes	n = 120	n = 8	n = 25	n = 51	n = 18	n = 34
Model 1	1.00 0.26	0.66 [0.32–1.35]	1.00 0.44	1.56 [0.97–2.53]	0.92 [0.50–1.69]	1.02 [0.61–1.71]
Model 2	1.00 0.11	0.56 [0.27–1.15]	1.00 0.17	1.55 [0.96–2.51]	0.88 [0.48–1.62]	0.88 [0.52–1.49]

* Mean ± standard deviation; ^† Reference quartile; Model 1, adjusted for age and gender; Model 2, adjusted for age, gender, body-mass index, supine systolic blood pressure, resting heart rate, antihypertensive treatment, diabetes, current smoking and total cholesterol