Fig. 4.

The dose–response study of S-1 given for treatment of Y-MESO-14 cells implanted in SCID mice. Y-MESO-14 cells were inoculated into thoracic cavity of SCID mice on day 0. The Y-MESO-14 cell-inoculated mice were daily treated with vehicle or with various doses of S-1 from day 7 to 20 and sacrificed on day 21. Treatment with S-1 was significantly effective to reduce tumor (a), and pleural effusion (b), in a dose dependent manner. The P values were obtained from Holm’s procedure (non-parametric Tukey test)