Fig. 6.

The effect of S-1 administration on the survival of MPM cell-bearing SCID mice. Y-MESO-14 cell-bearing mice were treated with vehicle or with S-1 (10 mg/kg, daily) for 10 days (day 11–20) or 14 days (day 7–20). There were significant differences between 10-day treatment and vehicle groups (P = 0.02) and between 14-day treatment and vehicle groups (P = 0.02). The median survival times were 31, 42 and 42 days in vehicle, 10-day and 14-day treatment groups, respectively. The probability of survival was calculated with the Kaplan–Meier method, and differences between curves were evaluated with the log-rank test