Figure 1.

Differentiation of dendritic cells (DCs) from haematopoietic stem cells (HSC). The HSCs differentiate into common lymphoid progenitors (CLPs) and common myeloid progenitors (CMPs); CMPs subsequently differentiate into monocytes and pre-DCs in the bone marrow. Subsequently, monocytes and pre-DCs enter the blood and migrate to lymphoid organs and peripheral tissues, where they give rise to lymphoid DCs and tissue-resident DCs. In addition to CMPs, CLPs also have the potential to give rise to DCs, but their contribution is not well understood.