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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Semin Hematol. 2011 Jul;48(3):214–226. doi: 10.1053/j.seminhematol.2011.05.001

Figure 1. Targeting cyclin-dependent kinases.

Figure 1

The cyclin-dependent kinases (CDKs) 1, 2, 4 and 6 are directly involved in the progression through G1/S and G2/M phases of the cell cycle. CDKs 7, 9 and 10 regulate transcription. Pan-CDK inhibitors exhibit activity against both groups, whereas PD0332991 selectively targets interphase CDKs.