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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Semin Hematol. 2011 Jul;48(3):214–226. doi: 10.1053/j.seminhematol.2011.05.001

Figure 3. Targeting the B-cell receptor signaling pathway.

Figure 3

The B-cell receptor signaling pathway is initiated through phosphorylation of co-receptors Igα (CD79a) and Igβ (CD79b), recruiting the tyrosine kinase SYK. In turn, SYK phosphorylates several downstream kinases including BTK and PI3Kδ. Activation of PI3Kδ and phospholipase C (PLC) generates PIP3 and diacylglycerol (DAG), respectively. DAG is necessary for activation of protein kinase C (PKC). Inhibitors targeting the signaling cascade downstream of the BCR in clinical development are indicated.