Table 1.
Transduction Patterns of Adeno-Associated Virus (Serotypes 1, 2, 5, 8, and 9) When Injected at Early, Intermediate, and Advanced Stages of Retinal Degenerationa
| AAV serotype | P20 | P30 | P60 |
|---|---|---|---|
| AAV1 | — | — | MC, INL, RPE |
| AAV2 | RGC, MC | RGC, MC, some INL, some RPE | RGC, MC, some INL, some RPE |
| AAV5 | MC, PR, RPE | MC, PR, RPE | MC, PR, RPE |
| AAV8 | MC, PR | MC, PR | MC, PR |
| AAV9 | MC, PR | MC, PR | MC, PR, some RPE |
Abbreviations: INL, inner nuclear layer; MC, Müller cells; P20, P30, and P60: early, intermediate, and advanced stages of retinal degeneration, respectively; PR, photoreceptors; RGC, retinal ganglion cells; RPE, retinal pigment epithelium.
a
Expression was seen primarily in Müller cells, photoreceptors, and retinal pigment epithelium, with some inner nuclear layer and retinal ganglion cell transduction.