Table 1.
Pathway Analysis Statistics
Pathway | Group enrichment P valuea | # of predicted targets in pathway for mock miRNA controls |
# of predicted targets in pathway for miRNAs in Table 2b | |
Mean controlb | Maximum controlb | |||
ECM-receptor interaction | 0.0046 | 22 | 36 | 45 |
Focal adhesion | 0.017 | 66 | 93 | 101 |
Small cell lung cancer | 0.039 | 24 | 33 | 39 |
NOTE. aThe group enrichment P value represents the enrichment of predicted targets for a pathway relative to mock-predicted targets.
bTwenty control miRNA sets were generated that had the same characteristics as the test miRNA family. The mean and maximum number of miRNAs in simulations from these control sets that are predicted to target the pathway are indicated, which can be compared with the actual number of observed miRNAs predicted to target the pathway. See Supplementary Data for more details.