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. 2000 Oct 15;106(8):951–961. doi: 10.1172/JCI10905

Figure 4.

Figure 4

Reduced VSMCs and pericytes in the Edg1–/– vessels. (a–d) EM microscopic analyses of representative small blood vessels from the limb (a and b) and brain capillaries (c and d) from E12.5 wild-type and Edg1–/– embryos. Reduced number of VSMCs (bracket in b) and the lack of capillary pericytes (PC) were found in the Edg1–/– embryos. Notice the abnormally rounded EC nucleus in the Edg1–/– capillary (d). (e and f) EC junctions (arrows) in wild-type and mutant embryos. Note the normal EC junction (EJ) in the Edg1–/– embryo (f). BC, blood cell. ×2,000 (a–d); ×50,000 (e and f).