Skip to main content
. Author manuscript; available in PMC: 2011 Sep 29.
Published in final edited form as: Cold Spring Harb Symp Quant Biol. 2011 Mar 29;75:345–356. doi: 10.1101/sqb.2010.75.030

FIGURE 6. Results and model for the relationship of Cot-1 repeat RNA to active and inactive X chromosomes.

FIGURE 6

A) Cot-1 repeat RNA (green) is present throughout the nucleoplasm of active chromosomes but is essentially absent within the interior core of the Xi, even though Cot-1 repeat DNA (red) is detectable within DAPI dense Barr Body (white). Thus the Xi has a core of silent repeat elements. The linescans through the Xi in a normal female fibroblast quantifies the sharp distinction between Cot-1 DNA enrichment and lack of Cot-1 RNA. B) Model for the loosely peripheral organization of genes on Xa, which on Xi becomes more striking and surrounds a compacted and silent inner core. We suggest that Cot-1 RNA may be expressed throughout the central regions of euchromatic interphase chromosome territories even though evidence indicates the central regions have fewer genes.