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Growth ratio over a range of multiple initial sizes (500 – 1500 nm) and aerosol number concentrations (3.9×105 – 1.0×107 part/cm3) as a function of (a) GC2 and (b) GC3. As aerosol number concentration increases above 3.9×105 part/cm3, use of both GC2 and GC3 produces an over prediction of growth due to two-way coupling. In contrast, GC4 is shown (c) to account for growth across a wide range of drugs, excipients, initial sizes, and number concentrations.
