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. Author manuscript; available in PMC: 2011 Jul 26.
Published in final edited form as: Mol Cell. 2010 Oct 22;40(2):294–309. doi: 10.1016/j.molcel.2010.09.022

Figure 3. Effects of HIF on multiple steps of cancer development.

Figure 3

HIF is stabilized by hypoxia and other nonhypoxic stimuli in many cancers. HIF activity in cancer has been associated with 1. putative cancer ‘stem’ cell maintenance and increased expression of genes involved in 2. proliferation and survival, 3. metabolism, 4. angiogenesis, 5. recruitment of infiltrating cells such as tumor-associated macrophages and bone marrow-derived cells, and 6. tumor cell metastasis. Some examples of HIF regulated genes and oncogenic pathways are given in parentheses.