Table 2.

KSHV-associated MCD response criteria

Response category	Response and criteria
Clinical response	CR
	Full resolution of all signs and symptoms attributable to MCD, lasting 1 cycle (3-4 wk depending on regimen); requires normalization of involved nodal areas on physical examination
	SFD
	Full resolution of all symptoms attributable to MCD
	PR
	Improvement in at least 50% of signs and symptoms by at least 1 grade (NCI-CTCAE, Version 3), with no increased MCD-related increases, lasting 1 cycle (3-4 wk depending on regimen)
	SD
	No change in signs and symptoms of MCD meeting criteria for CR, PR, or PD
	PD
	Worsening of 2 or more symptoms by at least 1 grade
Biochemical response*	CR
	Normalization of abnormalities attributed to MCD in the following laboratory values: hemoglobin, platelets, albumin, sodium, and CRP, lasting 1 cycle (3-4 wk depending on regimen)
	PR
	At least 50% improvement in all laboratory value abnormalities attributable to MCD, lasting 1 cycle (3-4 wk depending on regimen)
	SD
	No change in biochemical parameters that meet criteria for CR, PR, or PD
	PD
	≥ 25% and 1 grade worsening of at least 2 biochemical parameters attributable to MCD OR clear deterioration in one parameter with negative impact on physiologic or health status
Radiographic response	CR
	Normalization of all lymph nodes to < 1.5 cm in greatest transverse dimension, with decrease to < 1 cm of lymph nodes that measure 1.1-1.5 cm at baseline, or 75% decrease in SPD of measured lymph nodes; spleen < 12 cm greatest dimension, no pleural effusions
	Cru
	Residual lymph node mass > 1.5 cm or spleen > 12 cm that has decrease by ≥ 75% and does not change over 1 y
	PR
	For lymph nodes, ≥ 50% decrease in SPD of 6 dominant nodes; for spleen, ≥ 50% decrease in longest transverse dimension
	SD
	Not meeting criteria for CR, CRu, PR, or PD
	PD
	For lymph nodes, ≥ 25% increase in the SPD; for spleen, increase ≥ 25% in longest dimension
Overall response	CR
	CR in all categories
	PR
	PR or better in all categories
	SD
	SD or better in all categories
	PD
	Progression in any 1 category

Data are based on signs and symptoms probably or definitely attributed to KSHV-MCD.

CR indicates complete response; SFD, symptom-free disease; PR, partial response; NCI-CTCAE, National Cancer Institute Common Terminology Criteria for Adverse Events; SD, stable disease; PD, progressive disease; SPD, sum products of the diameters; and Cru, complete response, unconfirmed.

^*Determination of partial or complete biochemical responses was not based on improvements in hemoglobin or platelet counts that occurred within 3 weeks (one cycle) of transfusions or growth factor support.