Table 4.
Changes in biochemical parameters from baseline to time of best clinical response in patients with KSHV-MCD treated with AZT/VGC
| Parameter | n | Median baseline (range) | Median best clinical response (range) | Median change (range) | P |
|---|---|---|---|---|---|
| CRP, mg/dL | 14 | 7.5 (1, 35.9) | 0.5 (< 0.4, 23.2) | −7 (22.2, −29) | .0085 |
| Albumin, g/dL | 14 | 2.8 (1.5, 3.5) | 3.4 (1.4, 4.3) | 0.6 (−0.6, 2.4) | .0033 |
| Sodium, mEq/L | 14 | 134 (127, 142) | 136 (131, 141) | 0 (−6, 8) | .46 |
| Hemoglobin, g/dL | 14 | 10.1 (7.7, 12.7) | 11.2 (7, 14.1) | 0.85 (−2.2, 5.1) | .31 |
| Platelets, × 1000/μL | 14 | 115 (16, 347) | 206 (21, 477) | 71 (−103, 244) | .02 |
| hIL-6, pg/mL* | 13 | 17.9 (2.1, 171.5) | 5.8 (1.8, 192.2) | −5.4 (84.2, −123.7) | .027 |
| IL-10, pg/mL | 13 | 617 (5.6, 573 925) | 22.8 (1.7, 38 875) | −283 (33 000, −573,872) | .0002 |
| KSHV viral load, copies/106 PBMCs | 13 | 17 637 (0, 3.9 million) | 231 (0, 2.4 million) | −9787 (2.3 million, −2.8 million) | .021 |
Matched comparisons were performed using an exact Wilcoxon signed-rank test, using log10 transformation for hIL-6, IL-10, and KSHV viral load. Values for hIL-6, IL10, and KSHV viral load include only the 13 patients evaluable at both baseline and time of best clinical response.
*
Using this assay, the mean serum hIL-6 level in healthy donors is 2.3 pg/mL (SD 1.1 pg/mL).35