Fig. 2.

Stress response and swimming performance after cardiomyocyte ablation. (A) Survival of Z-CAT after a strong heat shock is given 7 and 14 days after vehicle or 4-HT injection. For each group, 9-13 zebrafish were assessed. Fisher Irwin exact test, ^*P<0.05. (B) Cartoon representing assay for swimming performance, in which adult zebrafish must swim to maintain position in a controlled current. (C) Maximum swimming speed of Z-CAT fish injected with vehicle or 4-HT at 7, 14 and 30 days post-injection (dpi). At each time point, 7-15 animals were assessed. Several vehicle-treated animals maintained swimming orientation throughout the 32-minute test periods; thus, 7 dpi data under-represent differences between the groups. ^*P<0.05, Student's t-test. Mean±s.e.m.