Figure 3.

Effect of duration of culture on the ability of supramaximal cerulein to cause trypsinogen activation (as assessed by measuring trypsin activity and TAP levels) and cell injury (LDH leakage) in pancreas fragments. Values are mean ± SEM obtained from at least three independent experiments and expressed as percent of maximal response obtained when freshly prepared pancreas fragments are stimulated with supramaximal dose of cerulein. ^AP < 0.05 when values obtained from cerulein-stimulated freshly prepared fragments are compared with the basal values.