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. 2011 Jun 8;286(30):26418–26423. doi: 10.1074/jbc.M111.251140

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Sulfated GAG dose response for hFGF19-induced signaling via hFGFR4/hKLB. Stable hFGFR4/hKLB/BaF3 transfectants (A) or stable hFGFR4/BaF3 transfectants (B) were stimulated with the absence (open circles) or presence of FGF (500 pm hFGF19 (filled circles) or 460 pm FGF1 (crosses)) together with the indicated concentrations of HS, CS-B, CS-E, or heparin (HP). Signaling was evaluated based on evoked DNA synthesis. All experiments were performed at least three times and yielded essentially the same results.