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CORM-2 causes damages to bacterial DNA. A, cell viability of E. coli recA mutant (white bars) and its parental strain (gray bars) grown under aerobic conditions and exposed to 150 μm CORM-2 and iCORM-2 was determined after 7 h. Error bars represent the mean ± S.E. (*, p < 0.05). Sensitivity tests were also performed in cultures treated with CORM-2 (+) and iCORM-2 (−). B, fluorescent microscopy of E. coli cells challenged, for 1 h, with 250 μm CORM-2, iCORM-2, and H2O2.
