CORM-2 impairs reduction of thiols by Ellman reagent. Production of 5-thio-2-nitrobenzoic acid, upon incubation, for 1 h, of increased amounts of iodoacetamide (▴), CORM-2 (●), and iCORM-2 (■) with glutathione were determined in the presence of Ellman reagent. Error bars represent the mean ± S.E.