FIGURE 4.

Sciatic nerve lipid composition in the Lpin1^1Hubr rat. A, the amounts of different lipid classes (see B for legend) as percentage of the total amount in lipid extracts derived from control (WT) and Lpin1^1Hubr rats at PND 16 or between PND 200 and 300 (“old”; n = 4). B, schematic overview of one part of membrane lipid synthesis in mammals (adapted from Ref. 27). DAG, diacylglycerol; Ins, inositol; CDP-Etn, cytidine diphosphate ethanolamine; CDP-Cho, cytidine diphosphate choline; Cds1, CDP-diacylglycerol synthase gene; CH, cholesterol. C, relative gene expression of Cds1 in sciatic nerve tissue of Lpin1^fld/fld mice as compared with wild-type mice at PND 56 (n = 4). D, relative gene expression of Cds1 in sciatic nerve tissue of Lpin1^1Hubr rats as compared with wild-type rats at PND 4, 10, 16, and 90 (n = 3, n = 3, n = 3, and n = 2 per group, respectively, *, p < 0.05; **, p < 0.01; ***, p < 0.0001). Data are expressed as mean ± S.E.