TABLE 1.

SRS in eukaryotic CYP51s

Residues (L. infantum numbering)	Secondary structural elementsa		SRS
	Substrate channel entrance	Substrate binding cavity
45–52	αA′		Unique for CYP51
101–115		αB′-B′/C loop	SRS1
123–129		αC	Unique for CYP51
207–213	αF″		SRS2
283–294		αI	SRS4
354–360		β1–4	SRS5
456–461	β4 hairpin		SRS6

^a Residues from these elements can be seen on the L. infantum electron density map in supplemental Fig. S1.