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. 2011 Jun 1;286(30):26913–26920. doi: 10.1074/jbc.M111.248203

FIGURE 4.

FIGURE 4.

CA coadministration overcomes the negative effects of GW4064 by restoring the BA pool. A, body weight of C57BL/6J mice after 76 days on different diets/treatments. Abbreviations are as in Fig. 1. Different doses of CA (0.125, 0.25, or 0.5% w/w) were supplemented to a high fat diet + GW4064. B, comparison of epWAT tissue weight after 76 days on the different diets. C, AUC of glucose levels during an OGTT after 60 days on the different diets. D, comparison of BA pool size and composition in enterohepatic organs in C57BL/6J mice treated with different diets for 10 days. Data are expressed as the mean ± S.E. (n = 5). *, p < 0.05, or **, p < 0.01, versus F and #, p < 0.05, or ##, p < 0.01, versus high fat diet + GW4064.