Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Changes in energy metabolism after FXR activation using GW4064. Administration of a synthetic FXR agonist to high fat fed mice leads to a reduction in bile acid synthesis and as a consequence to a reduced bile acid pool size. This translates into reduced energy expenditure in brown adipose tissue, TG accumulation in WAT, BAT, and liver, and insulin resistance.
