Figure 4.

Co-expressed granulocyte-macrophage colony stimulating factor enhances protection against infection from 25% to 71%. A, Kaplan-Meier curve for number of challenges to infection. P = .003 is the significance for the difference in number of challenges to infection between the GM-CSF-adjuvanted DNA (DgDgMM) and unvaccinated group (by log-rank Mandel-Cox test). B, Temporal post challenge viremia in animals that became infected. Infection dates are adjusted, with week 1 being the first week an infection was detected. Data are presented as means ± 1 standard deviation to show the differences in overall levels of viremia in the groups. The gray box represents the background for detection of viral RNA in the quantitative real-time polymerase chain reaction test. Data for the unadjuvanted DNA (DDMM) regimen are presented in turquoise, and those for the DgDgMM regimen are presented in fuchsia.