Figure 16.

Confidence, c, panels from $\Delta I_{f,\infty }$ for all groups used in our study. Pixels with absolute value below $c=2,3,\dots ,7$ are masked (colored black). Panels A–F were obtained using unfiltered RF: (A) MDA435-implanted mice injected with ${\alpha }_v{\beta }_3$-targeted nanoparticles ($N=5$), (B) MDA435-implanted mice injected with non-targeted nanoparticles ($N=5$), (C) MDA435-implanted mice injected with saline ($N=5$), (D)–(F) same injections into $N=5$ tumor-free mice. Panels A′ through B′ are the corresponding panels obtained using low-pass filtered RF. The smoothing spline parameter $S=0$ in all cases.