Figure 3.

Subsets (middle portion: $0.75\times 0.55\hspace{1em}\mathrm{cm}$) of smoothing spline $\log [E_f]$ images based on unfiltered (top row) and low-pass filtered (bottom row) RF obtained from a MDA435-implanted mouse injected with ${\alpha }_{\upsilon }{\beta }_3$-targeted nanoparticles. (A) Smoothing parameter $S=0$, (B) $S=0.5$, (C) $S=1.0$, (D) $S=2.0$ The RF used to construct these images was acquired immediately after injection.