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. 2011 Jul 21;2:37. doi: 10.3389/fphys.2011.00037

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Copyright © 2011 Behr, Longaker and Quarto.

This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

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Presence of specific chondrogenic markers in the differentiating COR suture mesenchyme. (A) Expression analysis of chondrogenic markers by qPCR showing a chondrogenic pattern of the differentiating COR suture mesenchyme in Twist1^+/− mice. By postnatal day 15 upregulation of osteocalcin (Oc) is observed, as result of the COR suture closure. (B) Immunohistochemistry for Sox9 and Col II confirm cartilage tissue formation in the COR suture of Twist1^+/− at day p11. Scale bar: 10 μm Expression analysis of chondrogenic markers by qPCR showing a chondrogenic pattern of the differentiating COR suture mesenchyme.