Scheme 3.
Synthesis of NVP-AUY922 beads (11).
Reagents and conditions: (a) NH2(CH2)6NHBoc (3), NaCNBH3, AcOH, MeOH, rt; (b) BC13, CH2C12, rt; (c) Affigel-10, DIEA, DMAP, DMF.
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