Table 1.

Patients with composite histology of atypical Burkitt's and follicular lymphoma

Patient	This case	1	2	3
Age	58	77	52	44
Sex	M	M	F	M
Site and stage at initial presentation	Submand LN + abd LN, ascites Stage III	Generalized LN + BM Stage IV	LN Stage III	LN + BM Stage IV
Temporal sequence of transformation	Concomitant	Concomitant	Concomitant	Concomitant
Histology	Composite Lymphoma	Composite follicular + Burkitt's	Composite Follicular + Burkitt's	Composite Lymphoma
Cytogenetics at transformation	t(14;18) by PCR + MYC translocation by FISH	t(14;18) + t(8;14)	t(14;18) in follicular area t(14;18) + t(8;14) in transformed area	t(14;18) + t(8;14)
Treatment	Chemo	Chemo	Chemo → CR	Chemo → CR
Outcome	Primary refractory died 13 months after Dx	Primary refractory and died 4 months after diagnosis	Relapsed 3 months later with partial response to salvage chemo	CNS relapse 6 months later and died
Reference		17	18	19

Abbreviations: F: female; M: male; LN: lymph node; FISH: fluorescent in-situ hybridization; NA: not available; BM: bone marrow;CNS central nervous system;

Dx: diagnosis; CR: complete remission; PR: partial remission; NR: non-remission;