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Suppression of the HNF4α and PGC-1α gene programs by post-translational modifications at different levels. Repression of overall PGC-1α activity will interfere with all gene programs coregulated by PGC-1α (A), whereas repression of HNF4α activity will affect all gene programs regulated by HNF4α (B). (C) Maximal specificity is achieved by specifically disrupting the interaction between HNF4α and PGC-1α to repress the PGC-1α-coregulated HNF4α gene program.
