Table 3A. Prevalence of skeletal involvement in patients with MPS II (n=124).
| Sign or symptom | N. patientsa | Median age (10th–90th percentile) at onset (years) |
|---|---|---|
| Kyphosis/scoliosis | 42 (33.8%) | 6.4 (0.6–15.9) |
| Claw hand | 66 (53.2%) | 4.2 (1.8–9.4) |
| Any joint stiffness | 93 (75.0%) | 4.0 (1.5–10.3) |
| Spine | 26 (21.0%) | 7.7 (1.6–15.4) |
| Shoulder | 68 (54.8%) | 4.6 (1.8–12.1) |
| Elbow | 74 (59.7%) | 5.1 (1.9–11.6) |
| Hand | 80 (64.5%) | 4.4 (1.9–10.2) |
| Hip | 35 (28.2%) | 5.6 (2.4–11.5) |
| Knee | 53 (42.7%) | 5.1 (2.3–11.6) |
| Ankle | 42 (33.9%) | 6.1 (2.6–11.6) |
a
Prevalences are calculated from birth to last visit for untreated patients and from birth to treatment start for treated patients.