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. 2009 Oct 10;1(2):e14. doi: 10.4081/or.2009.e14

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©Copyright G. Ishihara et al.,

This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0)

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Immunostaining of the degradative enzymes and their specific cleavage sites of aggrecan in the meniscus in stage 0. Column A. Inner-superficial zone of the meniscus (400×) Column B. Outer-deeper zone of the meniscus (400×). Immunostaining of MMP-3, aggrecanase 1, aggrecanase 2, DIPEN³⁴¹ (neoepitope of aggrecan generated by MMPs), and TEGE³⁷³ (neoepitope of aggrecan generated by aggrecanases) are shown.