Table 2.

Cancer incidence in first-degree relatives of index cases with breast cancer younger than age 41 but noBRCA1/BRCA2 germline mutation, and at least one additional case of breast cancer in a first-degree or second-degree relative

ICD-7	Site	Observed (n)	Expected (n)	Standardized incidence ratio	95% confidence interval
140–209	All malignant tumours	43	18.5	2.3	1.6–3.1
Non-170	All malignant tumours except breast	29	15.9	1.8	1.2–2.6
153	Large bowel	1	1.2	0.82	0.02–4.6
154	Rectum	2	0.82	2.4	0.30–8.8
162	Trachea and lung	3	1.5	2.0	0.42–5.9
170	Breast	14	2.6	5.3	2.9–9.0
171	Cervix uteri	2	0.39	5.1	0.62–18.5
175	Ovaries	1	0.50	2.0	0.05–11.0
177	Prostate	6	2.4	2.5	0.91–5.4
180	Kidney	2	0.74	2.7	0.33–9.8
181	Bladder and urinary tract	2	0.93	2.1	0.26–7.8
191	Skin nonmelanoma	1	0.50	2.0	0.05–11.2
193	Central nervous system	2	0.86	2.3	0.28–8.4
200 + 202	Non-Hodgkin's lymphoma	3	0.66	4.5	0.94–13.3

Age 0–79 years; n = 180; 6885.2 person-years; 1958–2000.