Table 3.

Cancer incidence in first-degree relatives ofBRCA1/BRCA2 carriers

ICD-7	Site	Observed (n)	Expected (n)	Standardized incidence ratio	95% confidence interval
140–209	All malignant tumours	20	7.3	2.7	1.7–4.2
Non-170	All malignant tumours except breast	12	6.2	1.9	1.0–1.6
151	Stomach	0	0.21	0	0–17.3
153	Large bowel	0	0.44	0	0–8.3
157	Pancreas	1	0.17	5.8	0.15–32.2
170	Breast	8	1.1	7.2	3.1–14.3
171	Cervix uteri	0	0.17	0	0–21.5
175	Ovaries	3	0.20	14.9	3.1–43.7
176	Vulva, vagina	1	0.02	45.6	1.1–254
177	Prostate	2	0.82	2.4	0.30–8.8
190	Melanoma	1	0.36	2.8	0.70–15.6
191	Skin, nonmelanoma	0	0.19	0	0–19.8
193	Central nervous system	1	0.40	2.5	0.06–13.9
194	Thyroid	1	0.17	5.9	0.15–33.0

Age 0–79 years; n = 82; 3106.4 person-years; 1958–2000.