Table 3.

Proportions of probands with a germline ancestral mutation in BRCA1 or BRCA2 out of total tested (percentages in parentheses), by personal cancer history and number of first-degree relatives with ovarian cancer, and with number of second-degree relatives with ovarian cancer

	No. of first-degree relatives with ovarian cancer			No. of second-degree relatives with ovarian cancer
Cancer status	0	1	2	0	1	2
No breast or ovarian cancer	10/131 (8%)	8/89 (9%)	0/7 (0%)	11/144 (8%)	1/4 (25%)	-
Breast cancer only	34/237 (14%)	13/42 (31%)	-	38/242 (16%)	4/5 (80%)	0/3 (0%)
Ovarian cancer only	4/18 (22%)	3/4 (75%)	-	5/20 (25%)	2/2 (100%)	-
Breast and ovarian cancer	3/3 (100%)	0/1 (0%)	-	3/4 (75%)	-	-