Table 3.
Demographic and Risk Factor Characteristics of Cohort Members with and without ONJ
| Kaiser Permanente Northwest |
HealthPartners |
|||||||
|---|---|---|---|---|---|---|---|---|
| Cases |
Non-cases |
Cases |
Non-cases |
|||||
| N = 17 |
N = 367,065 |
N = 6 |
N = 205,518 |
|||||
| N | % or Mean (SD) | N | % or Mean (SD) | N | % or Mean (SD) | N | % or Mean (SD) | |
| Mean age (yrs) (SD) | 62 (13) | 50 (13) | 54 (12) | 49 (12) | ||||
| Female | 13 | 76.5% | 192,497 | 52.4% | 3 | 50.0% | 108,213 | 52.7% |
| Dental insurance | 9 | 52.9% | 185,200 | 50.5% | 4 | 66.7% | 102,094 | 49.7% |
| Mean months enrolled (SD) | 76 (35) | 63 (34) | 82 (52) | 65 (46) | ||||
| Cancer | ||||||||
| Any cancer | 8 | 47.1% | 44,075 | 12.0% | 4 | 66.7% | 27,693 | 13.5% |
| Multiple myeloma | 1 | 5.9% | 286 | 0.1% | 3 | 50.0% | 460 | 0.2% |
| Breast | 1 | 5.9% | 6552 | 1.8% | 1 | 16.7% | 4842 | 2.4% |
| Oral | 5 | 29.4% | 8206 | 2.2% | 0 | 0.0% | 760 | 0.4% |
| Osteoporosis | 6 | 35.3% | 10,641 | 2.9% | 1 | 16.7% | 12,746 | 6.2% |
| Osteopenia | 1 | 5.9% | 2974 | 0.8% | 2 | 33.3% | 16,019 | 7.8% |
| Diabetes mellitus | 3 | 17.7% | 42,006 | 11.4% | 1 | 16.7% | 25,863 | 12.6% |
| Immune disorders* | 1 | 5.9% | 1402 | 0.4% | 0 | 0.0% | 1745 | 0.9% |
| Head and neck radiation | 2 | 11.8% | 4246 | 1.2% | 2 | 33.3% | 4142 | 2.0% |
| Oral bisphosphonates | 6 | 35.3% | 12,954 | 3.5% | 0 | 0.0% | 8203 | 4.0% |
| Mean days (SD) | 1465 (964) | 617 (656) | – | 643 (655) | ||||
| Mean dispenses (SD) | 26 (17) | 11 (12) | – | 14 (15) | ||||
| IV bisphosphonates† | 2 | 11.8% | 369 | 0.1% | NA | NA | ||
| Corticosteroids | 6 | 35.3% | 87,580 | 23.9% | 5 | 33.3% | 46,220 | 22.5% |
| Mean days (SD) | 363 (471) | 84 (298) | 120 (74) | 93 (323) | ||||
| Mean dispenses (SD) | 15 (21) | 4 (7) | 14 (3) | 4 (8) | ||||
| Any risk factor | 14 | 82.4% | 117,903 | 32.1% | 6 | 100.0% | 72,608 | 35.3% |
*
Immune mechanism disorders, includes diagnoses of AIDS/HIV and lupus.
†
Noted in the outpatient medical records only.