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Protective efficacy against swine-origin H1N1 influenza infection 6 weeks after vaccination. Survival (A) after challenge with 10×LD50 of live mouse-adapted virus. Body weight (BW) changes of challenged mice (B) were recorded during the infection period. Microneedle (MN) or subcutaneously (s.c.) vaccinated mice and placebo (uncoated) mice were monitored for 14 days after challenge. Data represent the mean ± standard error of the mean (SEM).
