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. 2011 Jul 26;9(7):e1001112. doi: 10.1371/journal.pbio.1001112

Figure 8. Anti-obesity effect of delivering HIF to the hypothalamus.

Figure 8

Age- and weight-matched C57BL/6 mice received mediobasal hypothalamic injection of neuron-specific lentiviruses expressing HIF2α/HIFβ (Lenti-HIF2α/HIFβ) (A&C), HIF1α/HIFβ (Lenti-HIF1α/HIFβ) (B&D), or GFP (Lenti-Control) (A–D). Mice were subsequently maintained under HFD feeding and monitored for body weight gain (A&B) and HFD intake (C&D). The control mice were shared by both groups but repeatedly presented in separate figures. Statistics show the difference between two mice groups at the time points indicated by lines. * p<0.05; n = 5–8 per group. Error bars reflect mean ± SEM.