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. 2011 Jul 26;6(7):e22168. doi: 10.1371/journal.pone.0022168

Table 2. Effect of a mutation in the B. burgdorferi hrpA (bb0827) or bb0826 gene on infection of C3H/HeN mice.

B. burgdorferi genotype Strain Total micea Day 7 Bloodb Day 7 Infection Day 21 Ear Day 21 Infection Day 35c Heart Day 35c Bladder Day 35c Joint Day 35c Ear Total sitesd Day 35 Infection
B31 5A4 (wt) GCB933 18 18/18 100.0% 18/18 100.0% 4/4 4/4 4/4 4/4 16/16 100.0%
hrpA2 GCB1164 3 0/3 0.0% 0/3 0.0% 0/3 0/3 0/3 0/3 0/12 0.0%
hrpA3 GCB1165 3 0/3 0.0% 0/3 0.0% 0/3 0/3 0/3 0/3 0/12 0.0%
hrpA4 GCB1166 3 0/3 0.0% 0/3 0.0% 0/3 0/3 0/3 0/3 0/12 0.0%
bb0826-3 GCB543 2 2/2 100.0% 2/2 100.0% 2/2 2/2 2/2 2/2 8/8 100.0%
bb0826-11 GCB544 2 2/2 100.0% 2/2 100.0% 2/2 2/2 2/2 2/2 8/8 100.0%
a

There is a large number of mice in the control group because the hrpA mutants were initially assessed as part of a larger group of mutants.

b

Values listed correspond to number of positive cultures/number of sites tested.

c

Four mice infected with B. burgdorferi 5A4 were chosen as positive controls for organ harvests at day 35.

d

Number of positive tissue sites/number of sites tested.