Table 1. Cure assessment of DB289 and DB766 combined or not with benznidazole (Bz) in murine model of acute T. cruzi-infection.¹ .

Experimental groups	Therapy route ( 2 , 3 )	Number of surviving/total number of animals	Assays performed after 60 days post treatment
			Number of negative hemoculture samples/number of mice	Number of negative blood PCR samples/number of mice
Uninfected		13/13	-	-
Untreated	-	4/15	0/4	0/4
Bz 50 mg/kg/day	p.o.	14/15	11/14	0/14
DB289 25 mg/kg	p.o.	5/6	2/5	0/5
DB289 25 mg/kg+Bz 50 mg/kg	p.o.+p.o.	6/6	1/6	0/6
DB766 50 mg/kg	ip	6/15	0/6	0/6
DB766 50 mg/kg+Bz 50 mg/kg	ip+p.o.	15/15	3/15	2/15
DB766 50 mg/kg	p.o.	3/7	1/3	1/3
DB766 50 mg/kg+Bz 50 mg/kg	p.o.+p.o.	8/8	0/8	0/8

¹Swiss male mice weight 20 to 24 g inoculated with 10⁴ blood trypomastigotes (Y strain).

Treatment was initiated at 5° dpi followed by 20 daily doses.

²Intraperitoneal – ip.

³per oral – p.o.