Table 2. Correlation of CRC pathology with T-cell density and SPARC expression.

Univariate analysis for Pathological features vs. SPARC, FOXP3, CD8 and CD45RO expression from patients with Stage II and III CRC
Features	Correlation coefficient	n	p value
SPARC
AJCC	−0.02	345	NS
Site, distal vs. proximal	0.03	336	NS
Grade, poor vs. well/moderate	−0.05	258	NS
Vascular invasion, yes vs. no	−0.04	299	NS
Lymphatic invasion, yes vs. no	0.02	198	NS
Perineural invasion, yes vs. no	−0.009	288	NS
Lymphatic response, yes vs. no	0.00	331	NS
Microsatelite instability, yes vs. no	−0.04	330	NS
FOXP3
AJCC	−0.04	329	0.0002
Site, distal vs. proximal	−0.05	321	NS
Grade, poor vs. well/moderate	−0.38	245	0.02
Vascular invasion, yes vs. no	−0.06	286	NS
Lymphatic invasion, yes vs. no	0.24	189	NS
Perineural invasion, yes vs. no	−0.41	275	NS
Lymphatic response, yes vs. no	−0.06	316	NS
Microsatelite instability, yes vs. no	0.11	315	NS
CD8
AJCC	−0.64	316	<0.0001
Site, distal vs. proximal	0.13	310	NS
Grade, poor vs. well/moderate	−0.19	232	NS
Vascular invasion, yes vs. no	0.01	272	NS
Lymphatic invasion, yes vs. no	−0.05	174	NS
Perineural invasion, yes vs. no	−0.69	261	0.01
Lymphatic response, yes vs. no	0.39	303	0.02
Microsatelite instability, yes vs. no	0.70	301	0.0001
CD45RO
AJCC	−0.61	33	<0.0001
Site, distal vs. proximal	0.18	325	NS
Grade, poor vs. well/moderate	−0.14	250	NS
Vascular invasion, yes vs. no	−0.12	289	NS
Lymphatic invasion, yes vs. no	0.10	193	NS
Perineural invasion, yes vs. no	−0.70	278	0.002
Lymphatic response, yes vs. no	0.26	319	0.055
Microsatelite instability, yes vs. no	0.59	318	<0.05

This table illustrates the correlation between different CRC pathological features and T-cell density or SPARC expression using univariate analysis.

Abbreviations: n- number, NS–not significant, AJCC – American Joint Committee on Cancer.