Skip to main content
. 2011 Jul 26;6(7):e22752. doi: 10.1371/journal.pone.0022752

Figure 3. Properties of the somata of PCs in response to tactile stimulation under voltage-clamp.

Figure 3

A. Under voltage-clamp (Vhold  =  −70 mV), the effects of SR95531 (20 µM) on the tactile stimulation (bar, 30 ms)-evoked somatic responses are shown. Arrows indicate the responses evoked by stimulation offset. Note that blockade inhibition revealed the stimulation-evoked action potentials, indicating a poor space clamping of this PC under in vivo conditions. B, Raster plot showing the peaks of the responses evoked by onset (On) and offset (Off) of the tactile stimuli (started at t = 0 ms). C, Representative current traces and mean values (± SEM) of the time to peak of the somatic responses evoked by tactile stimuli in ACSF (black; n = 12) and with SR95531 (gray; n = 6). The time point (0, left dashed line) indicates the onset of responses, and the right dashed line indicates the onset of inhibition. D, Under voltage-clamp (Vhold  =  −70 mV), the somatic response to tactile stimuli (bar, 30 ms) in ACSF, with NBQX (50 µM) and recovery (wash).