Skip to main content
. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Trends Genet. 2011 Jun 15;27(8):307–315. doi: 10.1016/j.tig.2011.05.004

Figure 3. Centrosome and cancer.

Figure 3

Possible mechanisms of how extra centrosomes could affect tumorigenesis. (A) Extra centrosomes can directly induce aneuploidy by forcing cells to undergo a multipolar intermediate during spindle assembly that lead to an increase of merotelic chromosome attachments and lagging chromosomes during mitosis. (B) Centrosome amplification can affect signalling, for example by modulating cilia number. (C) The presence of extra centrosomes can cause defects in asymmetric cell division in Drosophila neuroblasts, leading to an overproliferation of the stem cell population.